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KMID : 0624620140470120697
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BMB Reports
2014 Volume.47 No. 12 p.697 ~ p.702
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Celastrol inhibits gastric cancer growth by induction of apoptosis and autophagy
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Lee Hyun-Woo
Jang Kenny Seung-Bin
Choi Hye-Ji
Jo A-Ra
Cheong Jae-Ho
Chun Kyung-Hee
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Abstract
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Recently, the interest in natural products for the treatment of cancer is increasing because they are the pre-screened candidates. In the present study, we demonstrate the therapeutic effect of celastrol, a triterpene extracted from the root bark of Chinese medicine on gastric cancer. The proliferation of AGS and YCC-2 cells were most sensitively decreased in six kinds of gastric cancer cell lines after the treatment with celastrol. Celastrol inhibited the cell migration and increased G1 arrest in cell-cycle populations in both cell lines. The treatment with celastrol significantly induced autophagy and apoptosis and increased the expression of autophagy and apoptosis-related proteins. We also found an increase in phosphorylated AMPK following a decrease in all phosphorylated forms of AKT, mTOR and S6K after the treatment with celastrol. Moreover, gastric tumor burdens were reduced in a dose-dependent manner by celastrol administration in a xenografted mice model. Taken together, celastrol distinctly inhibits the gastric cancer cell proliferation and induces autophagy and apoptosis.
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KEYWORD
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Apoptosis, Autophagy, Celastrol, Chemo therapy, Gastric cancer
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